What is the role of Langerhans cells in the skin?

Langerhans cells play a crucial role in the immune system as antigen-presenting cells. These specialized cells are located in the epidermis, the outermost layer of the skin, where they serve as part of the body’s first line of defense against pathogens. When Langerhans cells encounter foreign invaders, such as pathogens or allergens, they capture and process these antigens. After processing, they migrate to the nearest lymph nodes, where they present the antigens to T cells, thus initiating an immune response.

This function is essential in helping the body recognize and respond to infections and other harmful substances, making Langerhans cells vital for maintaining skin health and overall immune function. Their ability to bridge the innate and adaptive immune systems demonstrates their importance in protecting the body against disease.